C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01)
Patent
CA 2740856
The present invention provides an anti-dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN; CD209) immunoglobulin single variable domain. Polypeptides, ligands and compositions comprising such anti-DC-SIGN immunoglobulin single variable domains are also described along with nucleic acids encoding such immunoglobulins and vectors and host cells for expression. The invention further relates to uses, formulations, compositions and devices comprising such DC-SIGN-binding agents.
La présente invention concerne un domaine variable unique dimmunoglobuline anti-agent de fixation dICAM-3 non-intégrine spécifique des cellules dendritiques (DC-SIGN; CD209). La présente invention concerne en outre des polypeptides, des ligands et des compositions comprenant de tels domaines variables uniques dimmunoglobuline anti-DC-SIGN avec des acides nucléiques codant pour de telles immunoglobulines et des vecteurs et des cellules hôtes pour expression. Linvention concerne en outre des utilisations, des formulations, des compositions et des dispositifs comprenant de tels agents de liaison de DC-SIGN.
Domantis Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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