C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) C07H 15/18 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2451650
The present invention relates to the design and synthesis of homogeneous A-L-P constructs, which contain a hepatic ligand to direct an oligomer or "payload" to a heptatocyte intracellularly via a receptor-mediated, ligand-directed pathway.
La présente invention se rapporte à la conception et à la synthèse de produits de synthèse A-L-P homogènes, qui contiennent un ligand hépatique permettant de diriger un oligomère ou une "charge utile" à un hépatocyte de manière intracellulaire par l'intermédiaire d'une voie dirigée par un ligand et facilitée par un récepteur.
Deamond Scott
Duff Robert
Roby Clinton
Ts'o Paul O. P.
Zhou Yuanzhong
Cell Works Inc.
Cell Works Therapeutics Inc.
Johns Hopkins University
Ridout & Maybee Llp
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