Light-induced killing of carcinoma cells

Details Light-induced killing of carcinoma cells Light-induced killing of carcinoma cells

C - Chemistry, Metallurgy

09

B

128/63, 327/1.2,

C09B 23/08 (2006.01) A61K 41/00 (2006.01) A61N 5/06 (2006.01) C09B 57/02 (2006.01)

Patent

CA 1338671

The invention relates to a method of killing carcinoma cells associated with normal cells using light of predetermined wavelength, said method comprising (a) contacting said cells with a chromophore at a predetermined concentration, said chromophore being characterized in that it is positively charged and sufficiently lipophilic to be taken up by said carcinoma cells and their mitochondria, it is retained substantially longer in the mitochondria of said carcinoma cells than in the mitochondria of said normal cells, or more of said chromophore is taken up by said carcinoma cells than by said normal cells contacted with said chromophore, it has a therapeutic index for light- induced cell killing of at least 500 for light of said predetermined wavelength; and it has a therapeutic ratio for light-induced killing of at least 50 for light of said predetermined wavelength, and (b) exposing said carcinoma cells to said light.

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