Lineage-directed induction of human mesenchymal stem cell...

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/12 (2006.01) A61K 35/28 (2006.01) A61K 38/18 (2006.01) A61K 38/20 (2006.01) A61K 38/22 (2006.01) A61K 38/39 (2006.01) C07K 16/28 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2211120

Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of choice as well as such compositions including isolated culture expanded human mesenchymal stem cells and bioactive factors effective to induce directed lineage induction are disclosed. Further disclosed is this method which also includes introducing such culturally expanded lineage-induced mesenchymal stem cells into a host from which they have originated for purposes of mesenchymal tissue regeneration or repair.

Cette invention concerne un procédé pour l'induction par lignée in vitro ou ex vitro de cellules souches mésenchymateuses humaines cultivées et isolées. Ce procédé consiste à mettre les cellules souches mésenchymateuses en contact avec un facteur bioactif capable d'opérer leur différenciation afin d'obtenir la lignée voulue. Cette invention concerne également des compositions contenant ces cellules souches mésenchymateuses humaines cultivées et isolées, ainsi que des facteurs bioactifs capables d'opérer l'induction par lignée. Cette invention concerne enfin un procédé consistant à introduire de telles cellules souches mésenchymateuses cultivées et induites par lignée dans un hôte dont elles sont issues afin de régénérer ou réparer les tissus mésenchymateux.

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