Linear adhesion inhibitors

Details Linear adhesion inhibitors Linear adhesion inhibitors

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) C07K 1/22 (2006.01) C07K 5/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/46 (2006.01) C07K 14/75 (2006.01) C07K 17/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2134418

Abstract Linear peptidos of the formula I X-A-Cys(R1)-B-Z I, in which A, B, R1, X and Z are as defined in Claim 1, are highly active inhibitors of the binding of the blood platelet integrin GP IIbIIIa (aIIb.beta.3) to natural ligands and are suitable, inter alia, for the prophylaxis and for the treatment of circulatory disorders, thrombosis, myocar- dial infarction, coronary heart disease, arteriosclero- sis, atherosclerosis, tumours and osteolytic diseases, and have a supporting effect in wound healing processes.

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