Linear chimeric olgonucleotide for modulation of expression...

Details Linear chimeric olgonucleotide for modulation of expression... Linear chimeric olgonucleotide for modulation of expression...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01)

Patent

CA 2233582

Genes coding for vascular cell adhesion molecules, particularly VCAM-1, are modulated through interaction of oligonucleotides with transcriptional regulatory factors which bind to the genes. Specific and effective oligonucleotides are provided which interact with the transcriptional regulatory factors to diminish their interaction with the genes and downregulate their function. Multi-modal oligonucleotides are also provided which interact both with a transcriptional regulatory factor and with another aspect of gene function.

Des gènes codant des molécules adhérant aux cellules vasculaires, en particulier VCAM-1, sont modulés par l'interaction d'oligonucléotides avec des facteurs de régulation transcriptionnelle qui se fixent sur les gènes. Sont décrits des oligonucléotides spécifiques et efficaces qui interagissent avec les facteurs de régulation transcriptionnelle afin de diminuer leur interaction avec les gènes et d'exercer une rétro-régulation de leur fonction. Sont également décrits des oligonucléotides multi-modaux qui interagissent aussi bien avec un facteur de régulation transcriptionnelle qu'avec un autre aspect de la fonction génique.

Affiliated with

Also associated with

Rating

Linear chimeric olgonucleotide for modulation of expression... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Linear chimeric olgonucleotide for modulation of expression..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Linear chimeric olgonucleotide for modulation of expression... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1837148