Linear substituted oligoalkyleneimine libraries

Details Linear substituted oligoalkyleneimine libraries Linear substituted oligoalkyleneimine libraries

C - Chemistry, Metallurgy

07

K

C07K 17/00 (2006.01) B01J 19/00 (2006.01) C07K 1/04 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2163240

Linear substituted oligoalkyleneimine molecules and libraries of molecules are disclosed, as an their methods of synthesis and use in acceptor binding assays. Each molecule or chain of a library contains the same number of 2 to about 10 substituted alkyleneimine repeating units whose substituents are reduced amino acid side chains bonded to the repeating units at a position alpha to the nitrogen atom, and the member chains of a library are present in equimolar amounts. The chains of a library contain one or more predetermined reduced amino acid side chain-substituted repeating units at one or more predetemvned positions of the substituted oligoalkyleneimine chain. The library contains equimolar amounts of at least six different reduced amino acid side chain-substituted repeating units at one or more of the same predetermined positions of the substituted oligoalkyleneimine chain. Particularly preferred linear substituted oligoalkyleneimine molecules and libraries are linear substituted oligoethyleneimines.

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