Lingo binding molecules and pharmaceutical use thereof

Details Lingo binding molecules and pharmaceutical use thereof Lingo binding molecules and pharmaceutical use thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2669181

The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human LINGO polypeptide, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with axonal degeneration and demyelination.

La présente invention concerne une molécule de liaison qui est capable de se lier au polypeptide LINGO humain, de singe cynomolgus et de rat, un polynucléotide codant pour une telle molécule de liaison ; un vecteur d'expression comprenant ledit polynucléotide ; un système d'expression comprenant un polynucléotide capable de produire une molécule de liaison ; une cellule hôte isolée qui comprend un système d'expression tel que défini ci-dessus ; l'utilisation d'une telle molécule de liaison en tant qu'un produit pharmaceutique, notamment dans le traitement destiné à promouvoir la régénération/plasticité axonale ; une composition pharmaceutique comprenant ladite molécule de liaison ; et un procédé de traitement de maladies associées à la dégénérescence axonale et à la démyélinisation.

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