Linked, sequence-specific dna-binding molecules

Details Linked, sequence-specific dna-binding molecules Linked, sequence-specific dna-binding molecules

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/4025 (2006.01) C07D 207/416 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2422520

The present invention concerns a DNA-binding molecule, capable of sequence- specific binding to the minor groove of double-stranded DNA, characterised in that it comprises at least two sequence specific DNA-binding elements, covalently linked to each other in tandem orientation by an amphipathic, flexible linker molecule, at least one of said DNA binding elements being non- proteinaceous.

La présente invention concerne une molécule liant l'ADN capable de liaison spécifique à la séquence au petit sillon de l'ADN à double brin, caractérisée en ce qu'elle comprend au moins deux éléments spécifiques à la séquence se liant à l'ADN, liés par covalence l'un à l'autre selon une orientation en tandem par une molécule de lieur amphipathique et souple, au moins un de ces éléments de liaison d'ADN n'étant pas protéinés.

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