Lipase-catalyzed acylation of alcohols with diketenes

C - Chemistry – Metallurgy – 12 – P

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C12P 41/00 (2006.01) C07C 29/09 (2006.01) C07C 29/88 (2006.01) C07C 33/26 (2006.01) C07C 67/46 (2006.01) C12P 7/02 (2006.01) C12P 7/62 (2006.01)

Patent

CA 2169301

A process for preparing acylated alcohols from alcohols is characterised in that the alcohol is reacted with a diketene in the presence of lipase. The process is particularly suitable for the enantioselective acetoacetylation of racemic alcohols.

Un procédé de préparation d'alcools acylés à partir d'alcools se caractérise en ce que l'on fait réagir l'alcool avec une dicétène en présence d'une lipase. Ce procédé est particulièrement utile pour l'acétoacétylation énantiosélective d'alcools racémiques.

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