Lipase from gastric mucosa

Details Lipase from gastric mucosa Lipase from gastric mucosa

C - Chemistry, Metallurgy

12

N

195/39.1, 195/1.

C12N 15/55 (2006.01) A61K 35/74 (2006.01) A61K 38/46 (2006.01) C12N 1/19 (2006.01) C12N 9/20 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1340970

A human gastric lipase protein for use in the treatment of lipase deficiency. A process is described for producing gastric lipase using recombinant DNA technology to produce a host organism (for example E.coli) capable of producing a methionine-gastric lipase or precursor of the gastric lipase which may be cleaved to yield the gastric lipase. The host organism is transformed with a vector including a gene coding for a methionine gastric lipase or a precursor of gastric lipase. The precursor protein is for example pregastric lipase protein, or a fusion protein comprising gastric lipase and a heterologous protein. A pharmaceutical composition in unit dosage or liquid form is described.

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