C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/20 (2006.01) A61K 38/46 (2006.01) A61K 38/54 (2006.01)
Patent
CA 2612648
The pharmaceutical use of lipases related to a variant of the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 1, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have an improved efficacy in vivo, are stable against protease-degradation, and/or are stable in the presence of bile salts.
L'invention concerne l'usage pharmaceutique de lipases et se rapporte à une variante de lipase Thermomyces lanuginosus (Humicola lanuginosa) comprenant des acides aminés 1-269 SEQ ID NO: 1, éventuellement en combinaison avec une protéase et/ou une amylase. Les exemples d'indications médicales sont les traitements de troubles digestifs, de l'insuffisance d'exocrine pancréatique (PEI), de la pancréatite, de la fibrose cystique, du diabète type I, et/ou du diabète type II. Les lipases de l'invention ont une meilleure efficacité in vivo, sont stables contre la dégradation de protéases et/ou sont stables en présence de sels biliaires.
Borch Kim
Gregory Peter Colin
Svendsen Allan
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
Novozymes A/s
Solvay Pharmaceuticals Gmbh
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