Lipid alcohols as new immunosuppressive and antiviral...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/10 (2006.01) A61K 31/045 (2006.01) A61K 31/08 (2006.01) A61K 31/13 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) C07C 317/18 (2006.01) C07C 323/25 (2006.01)

Patent

CA 2234244

The present invention relates to new immunosuppressive and antiviral drugs based on lipid alcohols of the general formulas (I) and (II), in which R1 is a straight or branched, saturated or unsaturated alkyl chain with 1-30 carbon atoms which can optionally be substituted once or repeatedly by halogen, or by one of the following groups: C1-C6-alkoxy, C1-C6-alkylmercapto, C1-C6-alkoxy- carbonyl, carboxy, C1-C6-alkylsulfinyl or C1-C6-alkylsulfonyl; R2 is a straight or branched, saturated or unsaturated alkyl chain with 1-20 carbon atoms which can optionally be substituted once or repeatedly by halogen, or by one of the following groups: C1-C6-alkoxy, C1-C6-alkylmercapto, C1-C6-alkoxy- carbonyl or C1-C6-alkylsulfonyl; X is a valency bond, oxicarbonyl, carbonyloxy, amido carbonyl, carbonyl amido, oxygen, sulphur, the sulfinyl group or the sulfonyl group; Y is a valency bond, oxicarbonyl, carbonyloxy, amido carbonyl, carbonyl amido, oxygen, sulphur, the sulfinyl group or the sulfonyl group; and n may be an integer of from 1 to 5. The invention also relates to the tautomers of said drugs, and combinations with other active substances, which combinations contain these compounds.

L'invention concerne de nouveaux médicaments immunosuppresseurs et antiviraux à base d'alcools lipidiques de la formule générale (I) et (II) où: R?1¿ représente une chaîne alkyle linéaire ou ramifiée, saturée ou insaturée avec 1 à 30 atomes de carbone, pouvant éventuellement être substituée une ou plusieurs fois par halogène ou un des groupes suivants: alcoxy C¿1?-C¿6?, alkylmercapto C¿1?-C¿6?, alcoxy-carbonyle C¿1?-C¿6?, carboxy, alkylsulfinyle C¿1?-C¿6? ou alkylsulfonyle C¿1?-C¿6?; R?2¿ représente hydrogène, une chaîne alkyle linéaire ou ramifiée, saturée ou insaturée avec 1 à 20 atomes de carbone, éventuellement substituée une ou deux fois par halogène ou un des groupes alcoxy C¿1?-C¿6?, alkylmercapto C¿1?-C¿6?, alcoxycarbonyle C¿1?-C¿6? ou des groupes alkylsulfonyle C¿1?-C¿6?; X représente un tiret de valence, oxycarbonyle, carbonyloxy, amidocarbonyle, carbonylamido, oxygène, soufre, le groupe sulfinyle ou sulfonyle; Y représente un tiret de valence, oxycarbonyle, carbonyloxy, amidocarbonyle, carbonylamido, oxygène, soufre, le groupe sulfinyle ou sulfonyle; et n est un nombre entier pouvant aller de 1 à 5. L'invention concerne également leurs tautomères et les combinaisons avec d'autres substances actives contenant ces composés.

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