Lipid-based dispersions useful for drug delivery

Details Lipid-based dispersions useful for drug delivery Lipid-based dispersions useful for drug delivery

A - Human Necessities

61

K

A61K 9/127 (2006.01)

Patent

CA 2551807

The invention provides lipid-based dispersion comprising comprising, a) phosphatidyl choline; b) an anionic phospholipid; optionally c) up to 1% cholesterol by weight of total lipids; and optionally d) a therapeutic agent; wherein the mean particle size measured by dynamic light scattering is less than 100 nm. The invention also provides pharmaceutical compositions comprising such a dispersion as well as methods of producing a therapeutic effect in a mammal comprising administering an effective amount of such a dispersion.

L'invention concerne une dispersion à base de lipides comprenant, a) la phosphatidylcholine; b) un phospholipide anionique; éventuellement c) jusqu'à 1 % de cholestérol en poids des lipides totaux; et éventuellement d) un agent thérapeutique; la taille moyenne des particules, mesurée par la diffusion de lumière dynamique, est inférieure à 100 nm. L'invention concerne aussi des compositions pharmaceutiques comprenant cette dispersion ainsi que des procédés pour produire un effet thérapeutique sur un mammifère, qui consistent à administrer une quantité efficace de cette dispersion.

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