Lipid cleavage enzyme

Details Lipid cleavage enzyme Lipid cleavage enzyme

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 47/48 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01) C07H 19/23 (2006.01) C12Q 1/44 (2006.01)

Patent

CA 2204908

A membranous enzyme not yet described in the state-of-the-art can be extracted from cellular membrane fractions of blood leukocytes or monocytes/macrophages. Also disclosed is the use of substrates of this enzyme to prepare medicaments that contain these substrates as pharmaceutical active substance. These medicaments are useful to direct pharmacologically active substances to target cells and to enrich target cells with said substances. Also disclosed are in- vitro research systems containing this enzyme used to detect other substrates of this enzyme.

L'invention concerne une enzyme membranaire non encore décrite dans l'état antérieur de la technique, qui peut être isolée de portions de la membrane cellulaire de leucocytes ou de monocytes/macrophages. L'invention concerne également l'utilisation de substrats de cette enzyme pour préparer des médicaments qui contiennent ces substrats comme principe actif pharmaceutique. Ces médicaments sont utiles pour libérer de manière ciblée des substances pharmacologiquement actives et pour en enrichir des cellules cibles. L'invention concerne en outre des systèmes de recherche in vitro contenant cette enzyme utiles pour détecter d'autres substrats de cette enzyme.

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