C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 9/127 (2006.01) A61K 47/22 (2006.01) A61K 47/26 (2006.01) A61K 47/34 (2006.01) C07D 233/36 (2006.01) C07D 295/13 (2006.01) C12N 15/113 (2010.01) C07H 15/04 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2760776
Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I).
La présente invention concerne des compositions lipidiques comprenant un lipide cationique de formule (I), un lipide neutre, un stérol et un polyéthylèneglycol(PEG) ou un lipide modifié par du PEG, ladite formule (I) correspondant à (F). L'invention concerne également des procédés de production du lipide cationique de formule (I).
Butler David
Jayaraman Muthusamy
Jung Michael E.
Manoharan Muthiah
Rajeev Kallanthottathil G.
Alnylam Pharmaceuticals Inc.
Stikeman Elliott S.e.n.c.r.l.,srl/llp
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