Lipid-comprising drug delivery complexes and methods for...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 47/48 (2006.01) C12N 15/09 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2445947

Novel stable, concentrated, biologically active and ready-to-use lipid- comprising drug delivery complexes and methods for their production are described. The complexes of the invention comprise a drug, at least one lipid species, optionally at least one polycation, and at least one targeting factor. The at least one lipid species may comprise a pegylated lipid. The complexes of the invention may provoke lower levels of inflammatory cytokines such as tumor necrosis factor-.alpha. (TNF-.alpha.). The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

L'invention se rapporte à des complexes d'administration de médicaments contenant des lipides, biologiquement actifs et prêts à l'emploi, ainsi qu'à leurs méthodes de production. Lesdits complexes comportent un médicament, au moins une espèce lipidique, éventuellement au moins un polycation, et au moins un facteur de ciblage. Parmi l'espèce ou les espèces lipidiques peut figurer un lipide pégylé. Lesdits complexes peuvent induire des niveaux inférieurs de cytokines inflammatoires telles que le facteur de nécrose tumorale .alpha. (TNF-.alpha.). La méthode selon la présente invention est conçue pour une production à grande échelle de systèmes d'administration de médicaments contenant des lipides pouvant servir à la thérapie génique ainsi qu'à d'autres applications.

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