Lipid construct for delivery of insulin to a mammal

Details Lipid construct for delivery of insulin to a mammal Lipid construct for delivery of insulin to a mammal

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 38/28 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/22 (2006.01) A61K 47/24 (2006.01) A61K 47/28 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2609402

The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.

La présente invention se rapporte à une composition ciblée sur les hépatocytes comportant de l'insuline associée à une construction lipidique contenant un lipide amphipathique et un lipide amphipathique étendu qui cible la construction sur un récepteur affiché par un hépatocyte. Cette composition peut comporter un mélange d'insuline libre et d'insuline associée au complexe. Cette composition peut être modifiée pour protéger l'insuline et le complexe de toute dégradation. L'invention se rapporte également à des procédés de fabrication de cette composition ainsi qu'à l'introduction de l'insuline dans la composition et au recyclage de divers composants de la composition. La présente invention se rapporte également à des méthodes de traitement atteints de diabète.

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