C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01) A61K 9/127 (2006.01) A61K 31/575 (2006.01)
Patent
CA 2458626
The invention concerns novel transfecting compounds consisting of an aminoglycoside bound to a lipid via a spacer, and their polyguanidyl derivatives. Said compounds are useful for in vitro, ex vivo or in vivo transfection of nucleic acids in different cell types.
L'invention concerne des nouveaux composés transfectants qui sont constitués d'un aminoglycoside relié à un lipide par l'intermédiaire d'un espaceur, et leurs dérivés polyguanidylés. Ces composés sont utiles pour la transfection in vitro, ex vivo ou in vivo d'acides nucléiques dans différents types cellulaires.
Lehn Jean-Marie
Lehn Pierre
Vigneron Jean-Pierre
Aventis Pharma S.a.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Centre National de La Recherche Scientifique
Institut National de La Sante Et de La Recherche Medicale
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