Lipid formulated compositions and methods for inhibiting...

Details Lipid formulated compositions and methods for inhibiting... Lipid formulated compositions and methods for inhibiting...

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) C12N 15/88 (2006.01)

Patent

CA 2754043

This invention relates to compositions containing double-stranded ribonucleic acid (dsRNA) in a lipid formulation, and methods of using the compositions to inhibit the expression of the Human kinesin family member 11 (Eg5) and Vascular En-dothelial Growth Factor (VEGF), and methods of using the compositions to treat pathological processes mediated by Eg5 and VEGF expression, such as cancer.

Cette invention porte sur des compositions contenant un acide ribonucléique double brin (ARN db) dans une formulation de lipides, et sur des procédés d'utilisation des compositions pour inhiber l'expression de l'élément 11 de la famille des kinésines humaines (Eg5) et du facteur de croissance endothéliale vasculaire (VEGF) et des procédés d'utilisation des compositions pour traiter des processus pathologiques à médiation par l'expression d'Eg5 et de VEGF, tels que le cancer.

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