Lipid-lowering quinazoline derivative

Details Lipid-lowering quinazoline derivative Lipid-lowering quinazoline derivative

C - Chemistry, Metallurgy

07

D

C07D 239/74 (2006.01) A61K 31/517 (2006.01)

Patent

CA 2338825

A novel carbonyl-substituted quinazoline, preferably 4-(3'-bromobenzoyl)-6,7- dimethoxyquinazoline (WHI-P164), and methods for lowering blood cholesterol, including reducing total cholesterol and LDL-cholesterol levels by administration of the carbonyl quinazolines and compositions thereof.

La présente invention concerne un nouveau quinazoline substitué par carbonyle, de préférence 4-(3'-bromobenzoyl)-6,7-diméthoxyquinazoline (WHI-P164), ainsi que des procédés hypocholestérolémiants, consistant notamment à faire baisser le taux de cholestérol total et le taux de cholestérol HDL par l'administration de quinazolines carbonyles et de compositions de ceux-ci.

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