C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 47/44 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2222328
Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. Upon removal of a solubilizing component (i.e, detergent or an organic solvent) the lipid-nucleic acid complexes form particles wherein the nucleic acid is serum-stable and is protected from degradation. The particles thus formed have access to extravascular sites and target cell populations and are suitable for the therapeutic delivery of nucleic acids.
L'invention concerne de nouveaux complexes d'acides nucléiques et de lipides, utiles pour effectuer des transferts de gènes in vitro et in vivo. On peut obtenir ces particules au moyen de procédés de dialyse à détergent ou de procédés utilisant des solvants organiques. Lorsqu'on supprime un constituant de solubilisation (c'est-à-dire, un détergent ou un solvant organique), les complexes d'acides nucléiques et de lipides forment des particules, l'acide nucléique présentant une stabilité au sérum et étant protégé de la dégradation. Ces particules peuvent alors accéder aux sites extravasculaires, ainsi qu'aux populations de cellules cible et sont appropriées pour l'administration thérapeutique d'acides nucléiques.
Bally Marcel B.
Cullis Pieter R.
Hope Michael
Reimer Dorothy L.
Scherrer Peter
Fetherstonhaugh & Co.
Inex Pharmaceuticals Corporation
Tekmira Pharmaceuticals Corporation
The University Of British Columbia
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