Lipid osmotic pump

Details Lipid osmotic pump Lipid osmotic pump

A - Human Necessities

61

K

128/104

A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/50 (2006.01)

Patent

CA 1264133

TITLE OF THE INVENTION LIPID OSMOTIC PUMP ABSTRACT OF THE DISCLOSURE The instant invention is directed to a lipid osmotic pump, comprising: (A) a core, comprising: (i) a beneficial amount of at least one substantially water insoluble active agent which is lipid soluble and/or lipid wettable; (ii) a sufficient amount of at least one water immiscible lipid carrier, which is liquid at the temperature of intended use, to dissolve and/or suspend said active agent; and (iii) a sufficient amount of at least one osmotic agent to ensure release of said lipid carrier from the pump; and (B) surrounded by a water insoluble wall: (i) having a thickness of about 1 to 1000 microns; - 2 - (ii) which is preferentially wetted by said lipid carrier over an aqueous solution of said osmotic agent; (iii) having a water permeability of about 1 x 10-18 to 4 x 10-15 cm3 sec/g; (iv) prepared from at least one polymer permeable to water but substantially impermeable to said osmotic agent; and (v) having a means for said active agent and lipid carrier to be released through said water insoluble wall.

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