Lipid particles on the basis of mixtures of liquid and solid...

A - Human Necessities – 61 – K

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Details

A61K 9/16 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2369594

The invention relates to lipid particles which do or do not carry active agents and comprise a mixed matrix consisting of solid and liquid lipid (so- called solid/liquid particles). The inventive particles are provided with a disordered structure (semicrystalline, mostly non-crystalline to amorphous) in the semisolid to solid condition of matter. The invention also relates to a method for producing said dispersions and especially a method for producing highly concentrated lipid particle dispersions with a lipid content of 30 % to 95 % or a solids content of 30 % to 95 % (lipid and stabiliser). Said dispersions are integer particles unlike the biamphiphilic cremes and/or the highly concentrated particle dispersions result in free-flowing particle dispersions when diluted with the outer phase.

La présente invention concerne des particules lipidiques portant et ne portant pas de substances actives et comprenant une matrice mélangée, constituée de lipides solides et liquides (appelées particules solides/liquides). Ces particules présentent une structure désordonnée (semi-cristalline, sensiblement non cristalline jusqu'à amorphe) dans l'état de la matière allant de semi-solide à solide. La présente invention concerne également un procédé pour produire de telles dispersions, notamment un procédé pour produire des dispersions de particules lipidiques hautement concentrées présentant une teneur en lipide allant de 30 % à 95 % ou une teneur en matières solides allant 30 % à 95 % (lipide et stabilisant). Dans ces dispersions, les particules sont entières, non pas comme dans les crèmes biamphiphiliques et/ou les dispersions de particules hautement concentrées donnent des dispersions de particules à écoulement libre lorsqu'elles sont diluées avec la phase extérieure.

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