Lipid-polymer conjugates and liposomes

Details Lipid-polymer conjugates and liposomes Lipid-polymer conjugates and liposomes

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2156901

A lipid-polymer conjugate for use in forming long-circulating lipsomes is disclosed. Thc conjugste includes a vesicle-forming lipid having convalently attached to its polar head group, one of the polymers: polyvinylpyrrolidone, polyvinylmethylether, polyhydroxypropol methacrylate, polyhydroxypropylmethacrylamide, polyhydroxyethyl acrylate, polymethacrylamide, polydimethylacrylamide, polymethyloxa- zoline, polyethylloxazoline, polyhydroxyethyloxazoline, polyhydroxypropyloxazoline, or polyaspartamide. A method for preparing liposomes containing the lipid-polymer conjugate is also disclosed.

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