Lipid-rich plaque regressing agents

Details Lipid-rich plaque regressing agents Lipid-rich plaque regressing agents

C - Chemistry, Metallurgy

07

D

C07D 307/82 (2006.01) A61K 31/00 (2006.01) A61K 31/343 (2006.01) A61K 31/352 (2006.01) A61K 31/423 (2006.01) A61K 31/437 (2006.01) A61K 31/4433 (2006.01) A61K 31/453 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 45/00 (2006.01) A61P 9/08 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01) C07D 307/93 (2006.01) C07D 311/16 (2006.01) C07D 311/18 (2006.01) C07D 311/92 (2006.01) C07D 311/94 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 413/12

Patent

CA 2429008

Lipid-rich plaque inhibitors containing compounds of the following general formula or salts thereof: wherein A is a cyclic hydrocarbon or the like; B is a heterocycle or the like; X and Y are each NR1- (wherein R1 is hydrocarbyl or the like) or the like; D is C1-3 alkylene or the like; E is NH- or the like; G is a free valency or the like; and Ar is aryl or the like, or alternatively D or R4, together with constituent atoms of B, may form a ring.

L'invention concerne des inhibiteurs de plaques riches en lipides contenant des composants de la formule générale suivante ou leurs sels. Dans la formule générale, A représente un hydrocarbure cyclique ou équivalent ; B représente un hétérocycle ou équivalent ; X et Y représentent respectivement NR?1¿- ( R?1¿ étant un NH- hydrocarbyle ou équivalent) ou équivalent; G est une valence libre ou équivalent ; et Ar représente Aryle ou équivalent ou bien, en variante, D ou R?4¿ avec des atomes constituants de B peuvent constituer un noyau.

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