Lipid structures and uses thereof

Details Lipid structures and uses thereof Lipid structures and uses thereof

G - Physics

01

N

G01N 33/92 (2006.01) C12Q 1/02 (2006.01) G01N 21/64 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2448719

This invention features in vitro methods of determining the rate and extent to which test compounds, such as drug candidates, enter, move within, and traverse lipid-associated barriers. This invention also features method that measure the accumulation, that is the partition coefficient, of test compounds in lipid structures relative to, e.g., an aqueous phase, as well as the rate of accumulation of test compounds in the lipid structures. In addition, the invention features lipid vesicles that contain fluorophores localized within the aqueous interior that can be employed in the methods described herein.

Cette invention concerne des méthodes in vitro permettant de déterminer le débit et l'étendue auxquels des composés d'essai, tels que des candidats-médicaments, entrent dans les barrières liées aux lipides, se déplacent à l'intérieur de celles-ci et les traversent. Ladite invention a également trait à une méthode permettant de mesurer l'accumulation, c'est-à-dire le coefficient de répartition, des composés d'essai dans des structures de lipides, par rapport, par exemple, à une phase aqueuse, ainsi que le taux d'accumulation des composés d'essai dans les structures de lipides. En outre, cette invention a pour objet des vésicules de lipides qui contiennent des fluorophores localisés dans l'intérieur aqueux qu'on peut utiliser dans les méthodes susmentionnées.

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