Lipids and their use, for example, in liposomes

Details Lipids and their use, for example, in liposomes Lipids and their use, for example, in liposomes

C - Chemistry, Metallurgy

07

C

C07C 237/08 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 47/16 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07C 271/22 (2006.01) C07C 279/14 (2006.01) C07C 317/28 (2006.01) C07C 323/58 (2006.01) C07D 207/16 (2006.01) C07D 209/20 (2006.01) C07D 233/64 (2006.01) C07H 21/00 (2006.01) C07K 1/107 (2006.01) C07K 14/47 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2246456

The invention concerns novel lipid compounds suitable for the transport of biologically active substances or molecules in cells. A preferred compound according to the invention is L-lysine-bis-(0,0'-cis-9-octadecenoyl-.beta.- hydroxyethyl)-amide dihydrochloride or one of its optical isomers. In addition, the invention concerns complexes of the novel lipid compounds with polyanions such as DNA and RNA, and ternary complexes of the novel lipid compounds with polyanions and polycations. Finally, the invention concerns liposome formulations made from biologically active substances and the novel lipid compounds, as well as methods of transporting polyanions, polycations or biologically active substances through biological membranes by means of the novel lipid compounds.

L'invention concerne de nouveaux composés lipidiques appropriés pour le transport de substances ou de molécules biologiquement actives dans des cellules. Un composé préféré selon l'invention est l'amido-dichlorhydrate de L-lysine-bis-(O,O'-cis-9-octadécénoyl- beta -hydroxyéthyle) ou un isomère optique de ce composé. L'invention concerne en outre des complexes de ces nouveaux composés lipidiques avec des polyanions tels que l'ADN ou l'ARN, ainsi que des complexes ternaires des nouveaux composés lipidiques avec des polyanions et des polycations. Enfin, l'invention concerne également, en plus des formulations de liposomes obtenues à partir des substances biologiquement actives et des nouveaux composés lipidiques, un procédé pour le transport des polyanions, des polycations ou des substances biologiquement actives, par membranes biologiques, au moyen desdits composés lipidiques.

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