Lipids for epidermal moisturization and repair of barrier...

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01) A61K 8/63 (2006.01) A61K 8/68 (2006.01) A61K 31/575 (2006.01) A61K 7/40 (1995.01) A61K 7/48 (1995.01)

Patent

CA 2137001

Disorders of the skin and mucous membrane that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of a formulation comprising certain of the three major epidermal lipid species or their structurally similar precursors, isomers, or analogs in certain proportion ranges. This invention utilizes the following lipid species in unique combinations of two or more components; cholesterol, an acylceramide, a ceramide, and essential and essential fatty acids. These combinations are effective both as moisturizing agents and agents for the restoration of barrier function. Some of these combinations are further enhanced by the addition of known moisturizers such as petrolatum and glycerine.

Des troubles de la peau et de la muqueuse caractérisés par une perte d'intégrité ou un dysfonctionnement de la barrière épidermique sont traités ou prévenus par l'application topique d'une formulation comprenant certains des trois principales espèces de lipides de l'épiderme ou leurs précurseurs, isomères ou analogues de structure similaire dans certaines proportions particulières. Cette invention utilise les espèces de lipides suivantes dans des combinaisons particulières de deux ou plusieurs composés : cholestérol, un acylcéramide, un céramide et des acides essentiels et acides gras essentiels. Ces combinaisons sont efficaces à la fois comme agents hydratants et comme agents de rétablissement de la fonction de barrière. Certaines de ces combinaisons sont améliorées par l'addition d'hydratants connus comme la vaseline et la glycérine.

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