C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 339/04 (2006.01) A61K 31/385 (2006.01) A61P 35/00 (2006.01) C07C 311/49 (2006.01) C07C 323/52 (2006.01) C07F 19/00 (2006.01)
Patent
CA 2348998
This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poison the pyruvate dehydrogenase complex specifically in such cells. This invention also provides for methods of using therapeutically effective amounts of the lipoic acid derivatives for the treatment of cancer and other diseases. The lipoic acid derivatives described herein have a wide range of preventive and therapeutic applications.
L'invention concerne l'identification d'une nouvelle classe d'agents thérapeutiques qui ciblent et détruisent de manière sélective les cellules tumorales et certains autres types de cellules malades, ainsi que des compositions comprenant des dérivés d'acide lipoïque attaquant spécifiquement le complexe pyruvate déshydrogénase dans ces cellules. L'invention concerne également des traitements contre le cancer et d'autres maladies, comprenant l'administration de quantités thérapeutiquement efficaces de dérivés d'acide lipoïque. Ces dérivés d'acide lipoïque présentent un large éventail d'applications thérapeutiques.
Bingham Paul M.
Zachar Zuzana
Sim & Mcburney
The Research Foundation Of State University Of New York
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