Lipoidal biopterin compounds

Details Lipoidal biopterin compounds Lipoidal biopterin compounds

C - Chemistry, Metallurgy

07

D

260/242.1

C07D 475/04 (2006.01)

Patent

CA 1256868

ABSTRACT The present invention provides lipoidal biopterin and tetrahydrobiopterin compounds of the general structure: Image wherein -R is absent when ring B has two double bonds, in which case the compounds have the general structure: Image -R is hydrogen when the two double bonds in ring s are absent, and -R' and R" are independently saturated or unsaturated, aliphatic hydrocarbon groups wherein the sum of the carbon units of R' + 2R" is greater than 10 but less than 33 and processes for making same. These processes comprise the steps of reacting the 1'-2'-di-0-R+-L- biopterin with a fatty acid halide, R'COOX and thereafter, if desired, reducing ring B by hydrogenation. The compounds provided by this invention are oil soluble and can readily be formulated as an oil based pharmaceutical useful for the treatment of phenylketonuria, Parkinsonism, depression, senile dementia, Alzheimer's disease and related biopterin deficiency diseases.

482987

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