A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01) A61K 39/385 (2006.01) C08B 37/00 (2006.01) C12P 19/04 (2006.01)
Patent
CA 2315746
A conjugate vaccine for Moraxella (Branhamella) catarrhalis comprising isolated lipooligosaccharide from which esterified fatty acids have been removed, to produce a detoxified lipooligosaccharide (dLOS), or from which lipid A has been removed, to produce a detoxified oligosaccharide (OS), which is linked to an immunogenic carrier. The vaccine is useful for preventing otitis media and respiratory infections caused by M. catarrhalis in mammals, including humans.
L'invention concerne un vaccin conjugué contre Moraxella (Branhamella) catarrhalis comprenant un lipooligosaccharide isolé dont on retiré des acides gras estérifiés pour produire un lipooligosaccharide détoxiqué (dLOS), ou dont on a retiré un lipide A pour produire un oligosaccharide détoxiqué (OS), qui est lié à un excipient immunogène. Le vaccin s'utilise pour la prévention de l'otite moyenne et des infections respiratoires provoquées par M. catarrhalis chez des mammaliens, y compris des humains.
Gu Xin-Xing
Robbins John B.
Sim & Mcburney
The Government Of The United States Of America
LandOfFree
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