C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/60 (2006.01) A61K 38/12 (2006.01) C07K 7/56 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2063018
103/AOR52 18266 TITLE OF THE INVENTION LIPOPEPTIDE DERIVATIVES ABSTRACT OF THE DISCLOSURE The present invention is directed to water-soluble derivatives of antibiotic lipopeptides having the formula. Image wherein R is H or OH and R' is a phosphono, sulfo or acyl radical possessing a charged group at neutral pH. The derivatives are esters but having a charged group, have good solubility properties in aqueous medium, rendering them more useful as therapeutic agents.
Balkovec James M.
Hammond Milton L.
Mathre David J.
Balkovec James M.
Hammond Milton L.
Mathre David J.
Merck & Co. Inc.
Swabey Ogilvy Renault
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