Lipopeptide derivatives

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/60 (2006.01) A61K 38/12 (2006.01) C07K 7/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2063018

103/AOR52 18266 TITLE OF THE INVENTION LIPOPEPTIDE DERIVATIVES ABSTRACT OF THE DISCLOSURE The present invention is directed to water-soluble derivatives of antibiotic lipopeptides having the formula. Image wherein R is H or OH and R' is a phosphono, sulfo or acyl radical possessing a charged group at neutral pH. The derivatives are esters but having a charged group, have good solubility properties in aqueous medium, rendering them more useful as therapeutic agents.

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