C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/18 (2006.01) A61K 31/215 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2498420
The present invention relates to the use of lipophilic diesters of the chelating agent 1,2-bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) for inhibition of proteolytic activities of certain metalloproteinases and of calpain. The invention further relates to methods for preventing, treating or managing MMP-related and calpain-related diseases or disorders in mammals comprising administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of said lipophilic diesters of the chelating agent BAPTA.
L'invention porte sur l'utilisation de diesters lipophiles de l'acide 1,2-bis(2 aminophénoxy)éthane-N,N,N',N'-tétraacétique (BAPTA), agent chélateur inhibant l'activité protéolytique de certaines métalloprotéinases et de la calpain. L'invention porte également sur des méthodes de prévention traitement ou gestion de maladies ou troubles liés à la MMP et à la calpain, consistant à administrer à un mammifère le nécessitant une préparation pharmaceutique comportant une dose à effet thérapeutique desdits diesters lipophiles du BAPTA.
Friedman Jonathan Eduard
Kozak Alexander
Reznitsky-Cohen Dalia
Striem Sarina
D-Pharm Ltd.
Gowling Lafleur Henderson Llp
LandOfFree
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