Lipophilic drug delivery vehicle and methods of use thereof

Details Lipophilic drug delivery vehicle and methods of use thereof Lipophilic drug delivery vehicle and methods of use thereof

A - Human Necessities

61

K

A61K 9/127 (2006.01)

Patent

CA 2541117

The invention provides compositions and methods for delivery of a bioactive agent to an individual. Delivery vehicles are provided that include a bioactive agent in disc shaped particles that include one or more lipid binding polypeptides circumscribing the perimeter of a lipid bilayer in which the bioactive agent is localized. Chimeric lipid binding polypeptides are also provided and may be used to add additional functional properties to the delivery particles.

L'invention concerne des compositions et des méthodes destinées à l'administration d'un agent bioactif à un individu. On utilise des véhicules d'administration renfermant un agent bioactif dans des particules discoïdales comprenant un ou plusieurs polypeptides se liant aux lipides entourant le périmètre d'une bicouche lipidique dans laquelle se trouve l'agent bioactif. On utilise également des polypeptides se liant aux lipides chimériques pouvant conférer des propriétés fonctionnelles additionnelles aux particules d'administration.

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