Lipophilic microparticles containing a protein drug or...

Details Lipophilic microparticles containing a protein drug or... Lipophilic microparticles containing a protein drug or...

A - Human Necessities

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A61K 9/50 (2006.01) A61K 9/10 (2006.01) A61K 9/113 (2006.01) A61K 9/16 (2006.01) A61K 38/00 (2006.01) A61K 38/21 (2006.01) A61K 38/27 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2324403

A lipophilic microparticle having an average particle size ranging from 0.1 to 200 µm, comprising a lipophilic substance and an active ingredient selected from the group consisting of a protein or peptide drug and an antigen, retains the full activity of the active ingredient, and when formulated in the force of an oil dispersion or oil-in-water emulsion, it releases in an in vivo environment the active ingredient in a controlled manner over a long period.

L'invention concerne une microparticle lipophile dont la granulométrie moyenne est comprise entre 0,1 et 200 mu m, renfermant une substance lipophile et un principe actif sélectionné dans le groupe constitué d'une protéine, d'un peptide ou d'un médicament peptidique et d'un antigène. Cette microparticule maintient l'activité complète du principe actif et une fois formulée sous forme de dispersion huileuse ou d'émulsion huile-dans-eau, elle lâche le principe actif dans un environnement in vivo de manière régulée sur une longue période.

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