Lipophilic muramyl peptides and processes for their manufacture

Details Lipophilic muramyl peptides and processes for their manufacture Lipophilic muramyl peptides and processes for their manufacture

C - Chemistry, Metallurgy

07

H

530/9

C07H 15/00 (2006.01) C07K 9/00 (2006.01)

Patent

CA 1183129

Novel lipophilic muramyl peptides and processes for their manufacture Abstract The invention relates muramyl peptide compounds, especially of the formula Image (D) (L) (D) in which R1 represents, for example, alkyl or phenyl, R3 represents, for example ) hydrogen or methyl. and R5 represents, for exampie, hydrogen or lower alkyl optionally substituted, for example, by hydroxy, mercapto, or methylthio, and in which one of the radicals A1 and A2 represents a group of the formula Image in which T represents the group of the formula -NH or -O, and Y represents an alkylene radical optionally interrupted by a radical of the formula -CO-O- or -CO-NH-, and in which W represents hydrogen and Z represents a hydroxy-substituted ethyl group, wherein at least one hydroxy group is esterified by a long-chained acyl radical or W and Z represent hydroxymethyl, wherein hydroxy is esterified by a long-chained acyl radical, and the other of the radicals A1 and A2 represents optionally etherified hydroxy ox optionally sub- stituted amino. The novel compounds have immunopotentiating properties.

356860

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