Lipophilic oligosaccharide antibiotic salt compositions

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01) A61K 47/48 (2006.01) C07H 9/04 (2006.01) C07H 13/08 (2006.01) C07H 17/04 (2006.01) C07H 17/08 (2006.01)

Patent

CA 2121345

Pharmaceutically acceptable compositions of matter comprising a lipophilic oligosaccharide antibiotic, e.g., the everninomicin-type antibiotic of formula (III), at least a stoichiometric amount of a base, e.g., NMG, an amount of, e.g., hydroxypropyl- .beta.-cyclodextrin, and optionally a pharmaceutically acceptable non-ionic surfactant, e.g., Tween-80, pharmaceutical compositions containing such compositions of matter, methods of treating and preventing susceptible bacterial infections in animals especially human beings as well as a method of preventing adverse reaction syndrome while simultaneously delivering an antiinfective amount of a lipophilic oligosaccharide antibiotic such as that of formula (III) to said animals as well as the use of the compositions of matter for the preparation of a medicament for such treating or preventing are disclosed.

Les compositions faisant l'objet de la présente divulgation sont acceptables sur le plan pharmaceutique et renferment un antibiotique oligosaccharidique lipophile, par exemple un antibiotique de type éverninomicine correspondant à la formule (III), au moins une quantité stoechiométrique d'une base, p. ex. NMG, une quantité par exemple de bêta-cyclodextrine hydroxypropylée, et de façon facultative, un surfactant non ionique acceptable sur le plan pharmaceutique, p. ex. du Tween-80, des compositions pharmaceutiques renfermant ces compositions, des méthodes de traitement et de prévention d'infections causées par des bactéries sensibles à ce produit chez des animaux, en particulier chez les êtres humains et une méthode de prévention du syndrome de réactions indésirables avec diffusion simultanée d'une quantité anti-infectieuse d'un antibiotique oligosaccharidique lipophile comme celui correspondant à la formule (III) chez ces animaux et l'utilisation des compositions pour l'obtention d'un médicament pour le traitement ou la prévention de ces infections.

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