Lipophilic peptide hormone derivatives

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/575 (2006.01) A61K 38/10 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 38/33 (2006.01) A61K 38/44 (2006.01) A61K 38/46 (2006.01) A61K 38/50 (2006.01) A61K 47/48 (2006.01) C07K 1/113 (2006.01) C07K 7/16 (2006.01) C07K 14/555 (2006.01) C07K 14/665 (2006.01) C12N 9/02 (2006.01) C12N 9/22 (2006.01) C12N 9/80 (2006.01) C12N 9/82 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2215739

A pharmacologically active peptide hormone derivative in which the parent peptide hormone has been modified by introducing either a lipophilic substituent, W, in the N-terminal amino acid or a lipophilic substituent, Z, in the C-terminal amino acid of the parent peptide hormone or an analogue thereof, said lipophilic substituent having from 8 to 40 carbon atoms, has a protracted profile of action.

L'invention concerne des dérivés d'hormones peptidiques pharmacologiquement actifs dans lesquels l'hormone peptidique primitive a été modifiée par l'introduction d'un substituant lipophile, W, dans l'acide aminé N-terminal, ou bien par un substituant lipophile, Z, dans l'acide aminé C-terminal de ladite hormone, ou bien encore par un analogue, le substituant lipophile en question ayant de 8 à 40 atomes de carbone. Les dérivés considérés présentent un profil d'action prolongée.

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