Lipophilic peptides for macromolecule delivery

Details Lipophilic peptides for macromolecule delivery Lipophilic peptides for macromolecule delivery

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 31/70 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2242246

Peptide-macromolecule for delivery of nucleic acid to a cell. The nucleic acid carrier includes a binding complex. The binding complex contains a binding moiety which noncovalently binds to the nucleic acid. The binding complex can also contain a binding moiety which is associated with a surface ligand, nuclear ligand or a lysis agent. These may be associated with the binding moiety by spacers. In addition, the carrier may include a nucleic acid with a combination of the above binding complexes or binding moieties.

Complexes peptides-macromolécules pour l'apport d'un acide nucléique à une cellule. Ce vecteur d'acide nucléique renferme un complexe de liaison. Ledit complexe de liaison comprend une fraction de liaison qui se lie de façon non covalente à l'acide nucléique. Le complexe de liaison peut également renfermer une fraction de liaison qui est associée à un ligand de surface, un ligand nucléaire ou un agent de lyse. Ces éléments peuvent être associés à la fraction de liaison par des espaceurs. En outre, le vecteur peut inclure un acide nucléique avec une combinaison des complexes ou des fractions de liaison mentionnés ci-dessus.

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