Lipophilic phosphoramide compounds and uses thereof

C - Chemistry – Metallurgy – 07 – F

Patent

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C07F 9/24 (2006.01) A61K 9/127 (2006.01) C07F 9/54 (2006.01) C07F 9/59 (2006.01) C07F 9/6506 (2006.01) C07F 9/6539 (2006.01) C07F 9/72 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2505414

The invention relates to a cationic lipophilic compound of general formula (I), wherein: a) R1 and <SP>R'1</SP> independently represent an alkyl chain, alkenyl chain, or polyalkenyl chain of 10 to 24 carbon atoms, the polyalkenyl chain being provided with 2 to 4 double bonds; b) R2 represents a hydrogen atom or an alkyl chain with 1 to 4 carbon atoms; c) R3 represents a group of formula (IIa), i.e. -(CH2)n-, or formula (IIb), i.e. -C(=NH)-NH-(CH2)n-, n representing one of the whole numbers 0, 1, 2, 3, or 4; d) A+ represents an organic cation; and e) X- represents an anion.

La présente invention a pour objet un composé lipophile cationique de formule générale (I) suivante: dans laquelle: a) R?1¿ et ?R'1¿ représentent chacun, indépendamment l'un de l'autre, une chaîne alkyle, une chaîne alcényle ou une chaîne polyalcényle de 10 à 24 atomes de carbone, avec la chaîne polyalcényle ayant de 2 à 4 double liaisons ; b) R?2¿ est un atome d'hydrogène ou une chaîne alkyle ayant de 1 à 4 atomes de carbone ; et R?3¿ est un groupe de formule (IIa) suivante : -(CH¿2?)¿n?- ou (IIb) suivante: -C(=NH)-NH-(CH2)¿n?- dans laquelle : - n est un entier égal à 0, 1, 2, 3 ou 4 ; et d) A?+¿ est un cation organique ; e) X?-¿ est un anion.

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