Lipopolysaccharide-binding and neutralizing peptides

Details Lipopolysaccharide-binding and neutralizing peptides Lipopolysaccharide-binding and neutralizing peptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/04 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C12Q 1/37 (2006.01) C12Q 1/56 (2006.01) G01N 33/579 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2146667

The present invention relates to substances which bind with high affinity to endotoxin (lipopolysaccharide [LPS]), and which are useful for the prevention or treatment of, for example, Gram-negative and Gram-positive bacterial sepsis, and for the treatment of bacterial and fungal infections as well as for neutralizing effects associated with heparin. The substances are LPS-binding peptides comprising an LPS-binding domain. In addition, the invention relates to DNA sequences encoding said peptides, recombinant microorganisms containing said DNA, pharmaceutical compositions containing the peptides of the invention, and diagnostic kits. The invention also encompasses methods for the detection and removal of bacterial LPS from solutions.

La présente invention se rapporte à des substances qui se lient avec une affinité élevée à des endotoxines (lipopolysaccharides [LPS), et qui peuvent être utilisées pour la prévention ou le traitement, notamment, de la septicémie bactérienne à Gram négatif ou à Gram positif, ainsi que pour le traitement d'infections bactériennes et fongiques et pour neutraliser les effets associés à l'héparine. Ces substances sont des peptides de liaison d'LPS comprenant un domaine de liaison d'LPS. En outre, l'invention se rapporte à des séquences d'ADN codant ces peptides, à des micro-organismes recombinants contenant ledit ADN, à des compositions pharmaceutiques contenant les peptides de l'invention, ainsi qu'à des kits diagnostiques. L'invention se rapporte également à la détection et à l'extraction d'LPS bactérien à partir de solutions.

Affiliated with

Also associated with

Rating

Lipopolysaccharide-binding and neutralizing peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lipopolysaccharide-binding and neutralizing peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lipopolysaccharide-binding and neutralizing peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1672956