Lipopolysaccharide decontamination

Details Lipopolysaccharide decontamination Lipopolysaccharide decontamination

B - Operations, Transporting

01

J

B01J 20/26 (2006.01) B01D 61/00 (2006.01) B01D 67/00 (2006.01) B01J 20/28 (2006.01)

Patent

CA 2711584

Materials and methods for the selective removal of lipopolysaccharide during the purification of molecules of biopharmaceutical interest are based on a polymeric substrate that binds lipopolysaccharide. Preferably, the polymeric substrate is selective for at least one of heptose and 2-keto-3-deoxyoctonic acid. The substrate can be formed by a process comprising: (i) contacting a homogeneous polymer solution and a template solution; (ii) carrying out a phase inversion of the resulting solution; and (iii) removing the template.

L'invention concerne des matières et des procédés pour le retrait sélectif de lipopolysaccharide durant la purification de molécules d'intérêt biopharmaceutique qui sont fondés sur un substrat polymère qui se lie au lipopolysaccharide. De préférence, le substrat polymère est sélectif pour au moins l'un parmi l'heptose et l'acide 2-céto-3-désoxyoctonique. Le substrat peut être formé par un procédé consistant à : (i) mettre en contact une solution polymère homogène et une solution modèle; (ii) à réaliser une inversion de phase de la solution résultante; et (iii) à retirer le modèle.

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