Lipopolysaccharides (lps) extracted from escherichia coli

C - Chemistry – Metallurgy – 12 – P

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C12P 19/04 (2006.01) A61K 39/02 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2402544

The invention relates to lipopolysaccharides extracted from E. coli DSM 6601. This LPS differs from the known LPS extracted from E. coli in particular with regard to the phosphorylated sugar moiety of the core and to the degree of polymerization of the O-chain. The A lipoid corresponds structurally and biologically to the classic type of E. coli. The inventive LPS is not only suitable for identifying the coli strain which carries it, but also provides the latter with a reduced pathogenic capability, whilst retaining its immunomodulative effect.

lipopolysaccharides issus d'<I>E</I>. coli DSM 6601. Ce lipopolysaccharide diffère des autres LPS issus d'<I>E</I>. coli connus, notamment dans la fraction sucre du noyau et dans le degré de polymérisation de la chaîne O. Le lipoïde A correspond en termes de structure et de biologie au type classique pour les <I>E</I>. coli. Le LPS décrit ne s'utilise pas uniquement pour identifier la souchecoli qui le porte, mais lui confère également un pouvoir pathogène réduit tout en maintenant son effet immunorégulateur. LIPOPOLYSACCHARIDES ISSUS D'ESCHERICHIA COLI L'invention concerne des lipopolysaccharides issus d'E.coli DSM 6601. Ce lipopolysaccharide diffère des autres LPS issus d'E. coli connus, notamment dans la fraction sucre du noyau et dans le degré de polymérisation de la chaîne O. Le lipoïde A correspond en termes de structure et de biologie au type classique pour les E. coli. Le LPS décrit ne s'utilsie pas uniquement pour identifier la souche coli qui le porte, mais lui confère également un pouvoir pathogène réduit tout en maintenant son effet immunorégulateur.

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