Lipoprotein fractionation

Details Lipoprotein fractionation Lipoprotein fractionation

A - Human Necessities

61

K

167/114

A61K 35/16 (2006.01) B01J 39/04 (2006.01) B01J 47/00 (2006.01)

Patent

CA 1240923

ABSTRACT A process is described for removing low density and very low density lipoproteins from blood plasma or serum and recovering the plasma or serum in a physiologically acceptable form. The method involves in a preferred embodiment passing plasma or serum through a cationic ion exchanger equilibrated with a physiologically acceptable saline solution. The ion exchanger is a water insoluble hydrophilic, water swellable cross-linked regenerated or microgranular cellulose matrix substituted with hydroxy C2-C4 alkyl group. The ion exchanger capacity is provided by sulphate groups substituted with from 2 to 6 meq/g. The take up of low density lipoproteins is enhanced by recycling the plasma through the column.

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