Lipoprotein lipase (lpl) variant therapeutics

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/46 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) C12N 9/20 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2370081

The invention provides for the use of a therapeutic derived from a truncated lipoprotein lipase protein (LPL S447X), including nucleic acids encoding such proteins, for the treatment of conditions including LPL responsive conditions, such as cardiovascular disease, hypertension, LPL deficiency, high triglyceride levels, low HDL-cholesterol levels or atherosclerosis.

La présente invention concerne l'utilisation d'un traitement obtenu à partir d'une protéine lipoprotéine lipase tronquée (LPL S447X), ainsi que des acides nucléiques codant ces protéines, destiné au traitement des états tels que les états sensibles à la LPL, comme par exemple les maladies cardio-vasculaires, l'hypertension, les carences en LPL, des taux de triglycérides élevés, des taux de cholestérol HDL faibles ou l'athérosclérose.

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