Lipoprotein lipase suppression by endotoxin-induced mediator...

Details Lipoprotein lipase suppression by endotoxin-induced mediator... Lipoprotein lipase suppression by endotoxin-induced mediator...

A - Human Necessities

61

K

167/139, 167/37

A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 16/38 (2006.01) C12N 5/06 (2006.01) C12P 1/00 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1208546

-59- ABSTRACT Mediator substances exhibiting inhibitory effect upon anabolic enzyme activity in mammals, are prepared by a method compris- ing gathering a sample of macrophage cells from a mammal, in- cubating a portion of the macrophage cells with a stimulating material that is associated with an invasive event, and incu- bating the macrophage cells to produce the mediator substance. The stimulator materials, for example, may include endotoxins, trypanosomes and the like, and the enzymes that may be obser- ved range from lipoprotein lipase, acetyl Coenzyme A carboxy- lase and fatty acid synthetase, to the inducers for red blood cells growth and differentiation. The mediator substance may be utilized to raise antibodies which would in turn find utili- ty in testing for the presence or amount of various invasive stimuli, such as infection and the like. Testing procedures and appropriate materials in kit form are also contemplated. The mediator substances may likewise be utilized in procedures as screening agents, to test for potentially effective anti- shock agents or chemicals.

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