Lipoprotein surfactant

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/60 (2006.01) C12Q 1/00 (2006.01) C12Q 1/61 (2006.01)

Patent

CA 2713024

A sensor for determining the amount of triglyceride and/or cholesterol in a sample, the sensor comprising: (a) a surfactant of formula (1) wherein each of R a, R b, R c, R d and R e is independently -OH, C1-C4 alkoxy or a group of formula -OCONH(CH2)m-CH3, -OCO(CH2)m CH3, O(CH2)m CH3, -S(CH2)m CH3, -O(CH2)n-A, - S(CH2)n-A, -OCO(CH2)m-CH3 or -NHCO(CH2)m-CH3, wherein m is from 4 to 20, m' is from 4 to 20, m" is from 4 to 6 or from 8 to 20, n is from 0 to 10 and A is a C3-C8 cycloalkyl group or a phenyl group, with the proviso that at least one of the groups R a, R b, R c, R d and R e is not -OH or C1-C4 alkoxy; and (b) an enzyme reagent for measuring triglycerides and/or an enzyme reagent for measuring cholesterol.

L'invention porte sur un détecteur permettant de déterminer la quantité de triglycéride et/ou le cholestérol dans un échantillon. Le détecteur renferme (a) un agent tensioactif de formule (1), chacun de Ra, Rb, Rc, Rd et Re étant indépendamment -OH, alcoxy en C1-C4 ou un groupe de formule -OCONH(CH2)m -CH3, -OCO(CH2)m CH3, O(CH2)m-CH3, -S(CH2)m-CH3, -O(CH2)n-A, -S(CH2)n-A, -OCO(CH2)m-CH3 ou -NHCO(CH2)m-CH3, m valant de 4 à 20, m' valant de 4 à 20, m' valant de 4 à 6 ou de 8 à 20, n valant de 0 à 10 et A étant un groupe cycloalkyle en C3-C8 ou un groupe phényle, à la condition qu'au moins l'un des groupes Ra, Rb, Rc, Rd et Re ne soit pas -OH ou alkoxy en C1-C4; et (b) un réactif enzymatique pour mesurer les triglycérides et/ou un réactif enzymatique pour mesurer le cholestérol.

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