Liposoluble platinum (ii) complex and preparation thereof

Details Liposoluble platinum (ii) complex and preparation thereof Liposoluble platinum (ii) complex and preparation thereof

C - Chemistry, Metallurgy

07

F

167/119, 260/429

C07F 15/00 (2006.01) A61K 31/28 (2006.01)

Patent

CA 1261864

ABSTRACT OF THE DISCLOSURE New derivatives of platinum (II) complex are herein provided, which are liposoluble and applicable as antimicrobial agents and anticancer agents specific to the affected parts of patients and selectively transferred to the parts if they are used in combination with a contrast medium such as lipiodol, the derivatives being represented by the following general formula: Image (wherein R1 and R2 may be identical or different with each other and represent an ammine optionally substituted with an organic substituent and they may be bonded together through a bivalent organic group and R3 is a saturated or unsaturated higher fatty acid, these derivatives being prepared by nitrifying a cis-dichloro-di-(substituted or unsubstituted)-ammine platinum (II) and then reacting the resulting aqua type product with a corresponding alkali metal salt of higher fatty acid.

503485

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