A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 31/513 (2006.01)
Patent
CA 2412165
Liposomal encapsulated benzoquinazoline thymidylate synthase inhibitor formulations are provided. The liposomes have improved pharmacokinetics and enhanced efficacy as anti-tumor agents compared to the free drug. The formulations include liposomes comprising at least one phosphatidylcholine, a cholesterol, and a benzoquinazoline thymidylate synthase inhibitor.
La présente invention concerne des préparations d'inhibiteur de benzoquinazoline thymidylate synthase encapsulé en liposome. Les liposomes possèdent des propriétés pharmacocinétiques améliorées et une efficacité renforcée en tant qu'agents antitumoraux comparés aux médicaments libres. Ces préparations comprennent des liposomes qui comprennent au moins une phosphatidylcholine, un cholestérol et un inhibiteur de benzoquinazoline thymidylate synthase.
Ashvar Claudine S.
Chiang Su-Ming
Emerson David L.
Hu Ning
Jensen Gerard M.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Osi Pharmaceuticals Inc.
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